Nasal Polyps

The data from the bioelectric study suggest that
nasal polyp epithelial cells have a normal luminal chloride
channel because Isoproterenol, a drug that increases
cAMP and activates protein kinase A, increases chloride
permeability. Amiloride, however, caused a greater
decrease in sodium absorption in nasal polyp cells than
in inferior turbinate mucosa. Amiloride is a specific
blocker of the apical sodium channel and decreases the
basal voltage and basal short circuit current. Thus,
Amiloride and Furosemide can be used as topical
agents in blocking sodium channels, and in this way,
they decrease water absorption and edema in the nasal
polyp mucosa.

In conclusion, polyp epithelia have increased sodium
absorption, most likely because of increased number of
open sodium channels. These results are consistent with
the hypothesis that increased epithelial fluid absorption
contributes to the development of nasal polyps.

Topical diuretics that can block
sodium absorption are a realistic and rational method
of treating patients with small nasal polyps, and in particular,
treating with topical diuretics after surgical
removal of massive nasal polyposis.



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