The hearing loss may be unilateral or asymmetric and can progress during or after cessation of therapy. Some degree of reversibility of the hearing loss sometimes is noted weeks to months after treatment. Protective agents, including antioxidants, show promise for preventing or reducing
aminoglycoside toxicity. More recently, the use of salicylates has been proposed.
A placebo controlled clinical trial in China has shown a beneficial effect from the use of aspirin during aminoglycoside administration.