Nasal Crohn’s Disease

Crohn’s disease is an idiopathic, chronic inflammatory process
affecting the bowel. This disease often leads to fibrosis and obstructive
symptoms. Crohn’s disease usually affects the GI tract
anywhere from the mouth to the anus. However, this pathology
very rarely involves the nasal structures. The expression
of disease in the nasal septum includes intermittent epistaxis,
chronic mucosal inflammation, obstruction, and occasionally
septal perforation. The condition itself is believed to be
the result of an imbalance between proinflammatory and antiinflammatory
mediators. The etiology is unknown. Of the 36%
of all patients afflicted by Crohn’s disease who have extraintestinal
involvement, those in whom the nasal septum is affected
make up a very small portion. Treatment of the underlying
pathology can be effective in treating the nasal manifestations,
but does not resolve them in all cases.


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