Nasal Myospherulosis

Myospherulosis is characterised by the presence of cystlike
spaces lined by flattened histiocytes and containing
clusters of brownish spherules resembling fungi.
They lie loosely or within sacs formed by thin
refractile membranes. The brownish spherules do not
stain with PAS or Gomori methanamine silver and their
morphology does not correspond to any known fungus.
They are found within fibrous granulation tissue,
which may show a foreign body reaction. The lesion is
usually found in patients who have had previous operations.
It is now recognised that the spherules are
extravasated red cells that have been altered by interaction
with traumatised fat or petrolatum-based ointments
and gauzes used in surgical procedures.



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